|
KMID : 0931320100100010032
|
|
대한상부위장관.헬리코박터학회지
2010 Volume.10 No. 1 p.32 ~ p.36
|
|
|
The Effect of Proton Pump Inhibitor ’On-demand’ Therapy on GERD in Children
|
|
Lee Ji-Hyuk
Kim Mi-Jin
Choe Yon-Ho
|
|
|
Abstract
|
|
|
Background/Aims: The purpose of this prospective study was to evaluate the effect of proton pump inhibitor (PPI) ’on-demand’ therapy on gastro-esophageal reflux disease (GERD) in children.
Methods: After 8 week-treatment with lansoprazole in patients with erosive reflux disease (ERD) or non-erosive reflux disease (NERD), 14 ERD and 10 NERD patients who showed partial improvement were treated with ’on-demand’ therapy for another 16 weeks. We evaluated symptom score, compliance, and adverse event at week 8 and week 16.
Results: In ERD patients, improvement was achieved in 50.0% (7/14) at week 8 and 71.4% (10/14) at week 16. In NERD patients, the rates were 60.0% (6/10) at week 8 and 80.0% (8/10) at week 16. Adverse event was found in one case (4.2%) with NERD, who had lower abdominal pain.
Conclusions: PPI was very effective and safe in treatment of children with ERD or NERD. The compliance of medication was good. In patients with partial improvement after 8 weeks’ initial treatment, ’on-demand’ therapy was very useful as a maintenance therapy, and ’on-demand’ therapy for the additional 16 weeks was more effective than 8 weeks’ treatment. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2010;10:32-36)
|
|
|
KEYWORD
|
|
|
GERD, ERD, NERD, PPI, On-demand therapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|